MTL - Rebirth 2002: Nano Life-v5 Chapter 21 Alzheimer's disease

It has been half a month since I returned to Dream Valley. During this time, Australia has not entered the waters of Dream Valley again.

On this day, at the bottom of the Dream Valley, Chen Yizhe discovered an interesting thing, that is, among the group of terrorists captured by Chen Yizhe in the underwater city, one of them was a patient with Alzheimer's disease.

Compared with depression, this disorder is more interesting to Chen Yizhe. To put it simply, any pathological changes in the brain are the points of interest to Chen Yizhe.

In the world, the number of Alzheimer's patients is increasing. According to the statistics of the American Alzheimer's Association, the number of Alzheimer's patients in the world now reaches 30 million. It is predicted that by 2045, this number will increase fourfold, which means that one in 100 people will suffer from Alzheimer's by then.

Alzheimer's disease brings a huge disease burden to countries around the world. According to statistics, in 2010, the global social cost of dementia has reached 604 billion US dollars. Therefore, more and more countries have begun to elevate the research and prevention of Alzheimer's disease to the national level.

The awkward reality, however, is that humans may know far more about the universe than they know about the brain. The pathogenesis of Alzheimer's disease remains a mystery to this day. Therefore, the development of drugs for the treatment of Alzheimer's disease has also continued to fail, making many people call this century's stubborn disease a "cemetery" for investment.

This disease will first deprive the patient of part of the memory, then independence, and eventually the patient will lose his personality. Of course, on Chen Yizhe's side, even if the brain loses its personality, it will not prevent the body from surviving in another way, and finally control The body will be a graphene neural network transistor.

Moreover, whether this body will have an independent personality on the graphene transistor like Song Feier is also a point of interest to Chen Yizhe.

Alzheimer's disease is initiated by messages of aging, which is the closest risk factor for the disease. Of course, this is just an intuitive feeling, not a mechanistic reasoning.

For example, the mechanism of human cells, once the death mechanism is induced, it means that the cells will be infected in batches like a domino effect and eventually die. The death mechanism of the brain is different. The neurons of the brain are different from ordinary cells. The information of aging will not be very fast. First, the synapse is lost, then the plaque is deposited, and then the inflammatory reaction, which triggers the hyperphosphorylation of the protein, and finally the nerve metamorphosis to death.

This can be divided into three stages, the first stage is induced injury, the second stage is chronic neuroinflammation, and the third stage is the change of normal cell function, which tends to lead to the process of neural deformation.

The patient at the Chen Yizhe base had mild symptoms at first, but since the graphene transistor was implanted in the brain, the disease developed rapidly.

This is because the nutrients that the brain needs are absorbed by the graphene transistors, and the brain that has already had problems is even more broken.

Some people may ask why Song Feier doesn't have such a situation. This is because the Black Widow's side mainly plays an auxiliary role, and Chen Yizhe also implanted a super capacitor on Song Feier to support the operation of the Black Widow. As for these terrorists, Chen Yizhe directly implants graphene transistors to allow the body's biological energy to support the operation of graphene transistors. In doing so, the brain will be further restricted, and it is very likely that these people will be in the later stage. There is an Alzheimer's situation.

For these terrorists, Chen Yizhe did not regard them as human beings at all, but even a tissue has their underwear, and it is difficult to be worthy of the people who have been killed by them without draining the most valuable of these terrorists.

The emergence of Alzheimer's patients is still a reaction between Black Widow and Chen Yizhe. Chen Yizhe is responsible for managing other creatures implanted with graphene transistors by escalating Black Widow's authority, and basically all the information of these creatures will be fed back to Black Widow. Here, the changes in the patient's brain are only known to the Black Widow.

But since the birth of Black Widow, Chen Yizhe really hoped that another independent carbon-based soul would appear, but so far there has been none. Even the two depressives among the terrorists have not found that their graphene transistor system has Emergence of independence.

This made Chen Yizhe very curious why Song Feier was able to fission out the black widow. The secrets contained in the human brain really made Chen Yizhe's heart itch. Therefore, seeing such an Alzheimer's patient, Chen Yizhe directly stopped Nano Weather The development of weapons suddenly shifted the research center to this patient. After all, the theory of weather weapons has been formed, and the next step is to continuously test the finished product.

Chen Yizhe wants to see if he can find out the specific cause of Alzheimer's disease through clinical trials and the observation of nanoworms in the microscopic world.

When viewing the brains of Alzheimer's patients in the microscopic world for the first time, Chen Yizhe found bright pink plaques in the patient's brain regions related to memory, like rocks damaged by climbing walls. Many neurons disintegrate, lose connections to other neurons, and then wander on the brink of death.

Moreover, the brains of patients with the disease are much smaller than those of ordinary people, which means that a large number of neurons may have died before, and brown patches can be seen everywhere in the cortex; at the same time, the nerve fibers are confused like weeds.

Brain atrophy and nerve cell necrosis are the symptoms of all patients with Alzheimer's disease, and Chen Yizhe also found that the beta amyloid protein and nerve fibers in the patient's brain were damaged.

It has also been said before that there are two completely different forms of cell death in living organisms. When a cell suffers acute and severe damage, the cell swells and ruptures, and the cytosol extravasation causes inflammation in the surrounding tissue, a process called necrosis.

Another way of cell death that is different from cell necrosis, which Chen Yizhe calls death apoptosis, has characteristic morphological and biochemical changes, and is the process of active cell death itself, also known as programmed cell death.

This second mode of death is involved in many physiological and pathological processes of the body, and plays a regulatory role. It regulates the balance between cell proliferation and renewal during the life activities of the body, and maintains the normal physiological functions of tissues and organs and the relative stability of the number of cells.

"All cell death is 'programmed' because cell death is caused by a series of special events." Chen Yizhe explained to Song Feier, "But at a certain point, cell death is not Inevitably, interfering with the process by which this chain of events occurs can prevent or at least delay cell death. Knowing when the doors of opportunity open and close is critical!"

"Uh, isn't this door already open to you if you want to open it, and closed if you want to close it?" Song Feier laughed.

Chen Yizhe has done experiments on the induction and closing of death information on several terrorists. There is an apoptosis-inducing factor in the human body, and it is the last "finalist" before the door is opened. It is the nerve cell in DNA excessive damage. It is produced when it is produced, and then sent to the nucleus, where it can immediately cause the disintegration of the cell's genetic material.

Once the apoptosis-inducing factor enters the nucleus, the cell will die no matter what.

During the microscopic observation, Chen Yizhe found that other molecules are helping the inducer to escape from the mitochondria, pass through the cell and finally enter the nucleus. According to modern human science and technology, as long as the molecules that accompany AIF can be identified, interference should be found. and chance of preventing cell death.

But for Chen Yizhe, he can use nanoworms to create fake inducer information to open the door of biological death, or he can use nanoworms to cut off the spread of inducer information to close the door to death.

"Actually, carefully subdivided, there are not only two ways for cells to die!" Although Chen Yizhe was talking, he continued to use nanoworms to control the brains of Alzheimer's patients.

"Are you referring to the brain?" Song Feier asked.

"Well! The classical definitions of cell necrosis and apoptosis are meaningless to the nervous system." Chen Yizhe nodded, "more precisely, the way of death of neurons is determined by the 'protector of the genome'-polyadenosine diphosphate Controlled by ribose polymerase. When cellular DNA damage occurs, this enzyme can act as a molecular sensor in the cell to recognize, bind to DNA breaks, and be activated to prepare for repair of DNA damage. However, if DNA damage occurs in cells Too bad, and the enzyme triggers a cascade of reactions that cause brain cells to die. Especially in response to traumatic brain injury, Parkinson's, and stroke!"

"What about depression?" Song Feier asked.

"Depression does not induce the death of brain cells, but a slight change in the cerebral cortex. It is like a computer that is constantly writing self-destructing programs." Chen Yizhe glanced at Song Feier and smiled. Said, "You don't need to worry about this problem now. Now the self-destruction program written in your brain will be directly erased by Black Widow, but this method is only a temporary solution. I will be sure in the later stage, and then directly from the brain hardware Repair it!"

"Can you fix my appearance and body by the way?" Song Feier laughed~www.novelbuddy.com~ Chen Yizhe looked at Song Feier up and down, "Your appearance and body are not good enough?"

Although Song Feier was wearing white lab clothes, it was difficult to hide her beauty and figure. Her fair and delicate skin was a bit pink against the white long coat, and the eyes on her beautiful melon seed face seemed to be able to Intriguing, that tall girl's figure can arouse a man's desire for protection.

Song Feier shook her head, "I want to be what you like."

"If what I like keeps changing, will you keep changing too?" Chen Yizhe asked with a smile.

Song Feier nodded without hesitation.

Chen Yizhe touched Song Feier's head with his right hand, and when he wanted to say something, he suddenly laughed.

"What's wrong?" Song Feier asked.

"After waiting for so long, the Australian warship finally appeared!" Chen Yizhe said with a smile.