MTL - Doctor’s Life Simulator-Chapter 307 Contributed to the world's most authoritative 3 journals "cell" magazine

Seeing that Qin Lang made a choice, Ming Dong was also very happy, and at the same time he was going to inspect Qin Lang again. If this little guy can really make some achievements, then he will win over and invest in him.

"Doctor Qin, I hope this cooperation will give us a good start for each other."

Ming Dong and Qin Lang shook hands, and he really admired Qin Lang as a young man.

Therefore, she also intends to send her daughter to Qin Lang, so that they can communicate and understand more.

Not to mention the talent in pharmaceuticals, at least in other aspects, Qin Lang must be very good, otherwise it is impossible to win the favor of Shen Xi and Wu Jizong, and he has made so many achievements at such a young age.

Even her husband, the president of the Second Affiliated Hospital of Zijingang, was not so outstanding when he was young.

Dong Ming also applauded Qin Lang's ability to start from the most basic animal laboratory.

After all, she came up step by step from the grassroots level. When Ming Dong was young, she was also an amazing talented woman, graduated from Karolinska Institutet.

Karolinska Institutet is one of the world's leading medical universities, especially for its pharmacy and pharmaceutical majors, ranking among the top three in the world, second only to Harvard University and the University of California, San Diego.

After graduation, Ming Dong worked for Pfizer for five years before returning to Ming's Pharmaceutical Group. He started as an ordinary pharmacist, and now he has inherited his father's mantle and has become a real giant in the pharmaceutical industry in Zhejiang Province.

After Ming Dong arranged for Tang Yue to send Qin Lang to Qin Lang, she also rushed to the next meeting, and her work intensity was still very high.

Tang Yue did not expect that Qin Lang and her mother would reach the first cooperation like this. Although she is not very interested in pharmaceuticals, the basic situation is still clear.

He also has some understanding of animal experiments in the process of developing new drugs.

In fact, she didn't quite understand Qin Lang's choice.

According to her judgment, the chance of producing results in the field of animal experiments is already very small, and it is not a good research direction.

It's just that Qin Lang is a very assertive person and doesn't listen to her own opinions, so Tang Yue didn't say much. All she could do was support him silently.

"Qin Lang, then you can come with me."

Of course Qin Lang is very grateful to Tang Yue for his help: "thank you then."

Not much, I am not going to tell her too much about the breeding of the inbred line of mice this time, and I will talk about it after the results are obtained and a paper is published.

After Qin Lang sat on Tang Yue's red Wrangler, he thought about the follow-up arrangements for himself.

Tang Yue also understood this very well, and didn't want to disturb Qin Lang, so she drove quietly.

About half an hour later, the two people reached the test base.

After achieving the goal, Qin Lang basically has a complete plan.

Qin Lang still likes Tang Yue's silence along the way. After all, he doesn't like a girl chattering when he is thinking about important things.

The two quickly arrived at the animal experiment base in the suburbs of Xiaoshan District.

The entire base covers an area of ​​more than 500 acres. As soon as you enter the door, you see the plan of the entire park. Tang Yue briefly introduced it to Qin Lang.

In the entire park, more than half of the area is used to breed and breed mice.

Qin Lang casually circled a 500-square-meter rat house in the area pointed out by Tang Yue.

Behind Qin Lang and Tang Yue, an uncle in his 40s came over. It was Wu Qingguo, the manager of the base.

Wu Qingguo's appearance is a bit sloppy, especially the stray hair on the outside of the bald head, which drifts in the wind to give the impression of a fire cloud evil spirit. However, under the sloppy appearance, there are a pair of deep eyes.

It is not easy to be the person in charge of the animal experiment base of Mingshi Group.

Wu Qingguo is also a serious graduate of Huaguo Pharmaceutical University. He is regarded as a serious professional talent in China. He also entered the field of animal experimental research from the university. Improved design of the rat rack.

It can be said that in the field of animal experiments, there are many experiences and a lot of hard work, but luck is not very good, the papers studied and the patents applied for have not caused much splash.

After all, in the field of mice, foreign standards are used. Domestic pharmaceutical companies would rather spend more to introduce mature and advanced foreign technologies than invest in their own domestic research projects.

Wu Qingguo also went to work in Huaguo Johnson & Johnson Pharmaceutical Group for a period of time, but he did not get much attention. So, after working for six or seven years, he became a Buddha and returned to Xiaoshan, Hangzhou, and joined Mingshi Pharmaceutical Group.

The animal experiment base here is not a very important field for the Ming Group, and it is also cultivated by ordinary Kunming, and he does not have too many requirements.

Therefore, Wu Qingguo is also just doing his best without making any mistakes.

Standing aside, listening to the exchange between Tang Yue and Qin Lang, he had a general understanding that Qin Lang was a graduate student of Zijingang University, doing research in the field of animal experiments, and Director Ming valued and invested in him, providing him with free venues and facilities. The experimental mice, as well as the cooperation of their own staff.

In this regard, Wu Qingguo did not have much mood swings, nor was he too optimistic about Qin Lang's research. After all, in the mouse field, no matter how much he struggled, he would not be able to break through the mature system abroad, nor would he be able to make a big splash.

Zijingang's master's research on experimental animals is not as important as the research he once did in the University of Pharmacy.

"I hope this kid doesn't get too deep into himself. After all, research on experimental animals is of little value and won't produce much."

Wu Qingguo sighed inwardly, but he didn't express it. Moreover, in his opinion, this young graduate student probably took some mice from here for free for research.

"Qin Lang, in terms of animal experiments, I don't understand more professional things. Then if you need anything in the future, you can explain to Master Wu. He is very professional. After that, everything in the 500-square-meter area is at your disposal. ."

Tang Yue explained, and was about to go to the car outside to wait for Qin Lang. In fact, she was not very interested in these mice.

"Doctor Qin, then you can go to the mouse house with me."

Wu Qingguo led the way lazily. In his opinion, this young man was only hot for three minutes.

"Okay, Master Wu will trouble you later."

Qin Lang smiled slightly and followed Wu Qingguo.

Soon the two of them came to the mouse house area belonging to Qin Lang.

As soon as he walked into the mouse house, Wu Qingguo began to introduce it. After all, this was his only pleasure here:

"The quality of the feeding facilities and feed of the experimental animals directly affects the quality of the mice. Choosing the best feeding facilities and feed is the key to raising the mice. Classification management and optimization of breeding to improve the output of the laboratory mice are also the bases. the greatest pursuit.”

Qin Lang agrees very much that the mouse information unlocked by the animal laboratory has a lot of knowledge in his mind, and he is trying to confirm it. After all, he will start to breed guinea pigs, and these mouse houses are his cash cows, of course. To adjust to the best.

Wu Qingguo took Qin Lang into the first mouse house, and then introduced:

"Doctor Qin, this rat house looks ordinary, but it's actually a lot of attention. The reason why it is designed like this is because the mice prefer a dark and quiet environment, are very sensitive to the ambient temperature and humidity, and cannot withstand sudden changes in temperature. change and excessive temperature..."

When Wu Qingguo introduced it, Qin Lang also blurted out:

"The mice that have been artificially reared for a long time have poor adaptability to the environment, are not resistant to cold and heat, and are required to live in a clean and dust-free environment with fresh air, a temperature of 18-22°C, a relative humidity of 50-60%, and a noise below 85 decibels. Ammonia concentration of 20PPm. In an environment with ventilation 8 to 12 times/hour."

Qin Lang walked directly to the front of the monitoring equipment, looked at it carefully, and said with approval:

"Master Wu, your control here is still very good, but the ammonia concentration and relative humidity still need to be optimized."

Hearing Qin Lang's question, Wu Qingguo was stunned. Of course he knew what Qin Lang said about the optimal conditions, but in reality, there are many rat houses in the country. Moreover, the guinea pigs in this rat house were originally Normal grade instead of SPF grade.

"Is this young doctor an expert?"

Wu Qingguo put away his lazy thoughts a little, while Qin Lang went straight to the feed of the mouse house, pinched it out with three fingers, and then smelled it, his face changed slightly, obviously not satisfied:

"Master Wu, your feed formula needs to be improved!"

Wu Qingguo frowned. The feed he used was the most commonly used feed in China, and the hygiene and cleaning were well controlled. Qin Lang said this, but he was hitting him in the face.

Wu Qingguo's tone was a little cold: "Doctor Qin, you can't talk nonsense. I have been using this feed for decades, and there will be no problem."

Qin Lang turned his head to look at Wu Qingguo, and said calmly: "Of course the feed can be used like this, but I think it can be more optimized."

Wu Qingguo was stunned for a moment. The young man was a bit outspoken, and said unconvinced, "Oh, then please ask Dr. Qin for guidance."

Qin Lang pointed to the growth and feeding record card on the wall of the mouse house, and said, "Mice are omnivores, with a small stomach capacity, usually 1-1.5 ml. There is no problem with this basic feeding amount."

Hearing what Qin Lang said, Wu Qingguo nodded slightly. He didn't expect that Doctor Qin knew the market quite well. It seemed that he had done a lot of homework.

"However, Master Wu, have you ever paid attention to the feed consumption of mice, which varies with the different stages of growth, development and production and reproduction. For pregnant female mice, the feed consumption gradually increases. 12 to 21 days old after giving birth, The young mice start to open their eyes, their weight increases, and the amount of milk and feed also increases. The daily feed consumption increases from 4 grams to 5.5-6 grams from the 21st day of weaning to the 35th day, and the weight gain is the fastest. After 35 days of age, it gradually stabilizes. Therefore, the feeding of mice must be carried out according to the growth and development characteristics of different stages, and obviously, the current feeding amount and the growth cycle of mice are not perfectly combined. "

Hearing Qin Lang's analysis, Wu Qingguo was slightly taken aback. Of course, he knew that the amount of feed at different stages would not be used, but they were generally fed according to experience, and he had never thought of doing it so accurately.

Moreover, he arranged the feeding of the entire experimental base before. He was the most experienced, and his in-charge leaders did not understand at all, and would not pay attention to such details.

Wu Qingguo looked at Qin Lang's young face, and the old face was slightly red, but, how young is this doctor Qin, how can he be so familiar with the details of this feed?

Qin Lang continued to walk in the mouse house, and then walked to the position of the young mouse that had just opened its eyes and just weaned, and continued to add:

"The young mice can be fed pellets or soft materials with higher nutrition to meet their growth and development needs. As for female mice during lactation, in order to increase milk production, they should be fed with sunflower seeds throughout the lactation process, controlled at 1 gram, about 1 gram. At 12 capsules. Then, cod liver oil and vitamin dosage should be optimized in combination with the growth cycle, and then I will give you a detailed feeding plan."

Qin Langfeng said softly, and then continued to signal: "Master Wu, you can show me other areas."

Wu Qingguo nodded, the contempt in his eyes was completely gone, this Doctor Qin was really amazing.

"After that, when I decide on the formula of the feed, I will feed it all according to the formula. Remember not to change it frequently. The instability of the feed variety will cause the mice to grow stagnant and reduce their fertility."

Qin Lang asked again.

Wu Qingguo opened his mouth, but couldn't say a word.

In the past, every time my leader came to visit the mouse house, he always talked incessantly, and the leader listened carefully. A timely statement: OK, Master Wu, everything is based on your experience!

This time, in front of the young Qin Lang, Wu Qingguo felt a lot of pressure.

After another inspection, Qin Lang provided some comprehensive and systematic optimization suggestions for mouse boxes, mouse racks, drinking fountains, and bedding according to the advanced mouse-related theories provided by the drug research and development laboratory.

As a result, Wu Qingguo had an illusion that Ming Dong was an expert consultant invited from a top foreign animal laboratory.

Half an hour later, Qin Lang finished inspecting the 500-square-meter rat house that belonged to him.

"Master Wu, then according to the opinions I put forward today, we will improve and optimize the Wubaiping Rat House. I will come back in a few days to make arrangements for the next step."

During the inspection process, Qin Lang had already thought about the next arrangement. After returning to his teacher's tumor prevention and control center, he adjusted the research and development of new anti-tumor drugs to the induction and cultivation of ICR inbred mice.

Then, with the help of the laboratory of the Cancer Prevention and Control Center, the first batch of ICR mice were induced and cultivated, and sent to the mouse house of Mingshi Pharmaceutical Group for cultivation and mass reproduction, earning the first pot of gold.

When Qin Lang was thinking about the next plan, Wu Qingguo finally couldn't help it and asked:

"Doctor Qin, it will cost a lot of money to improve it according to your plan. Although it can indeed increase the reproduction rate and growth rate of the mice, the cost and benefits are not too high."

"Moreover, the improvements you proposed, I believe, can be achieved in top foreign animal laboratories, and have even been implemented. So what is the significance of your research?"

Although somewhat admired, from his experience and perspective, Qin Lang's small-scale optimization is not of much research value.

Perhaps for a master student, it is possible to write a thesis, but from a pharmaceutical company of the size of Mingshi Pharmaceutical Group, it is tasteless, tasteless, and a pity to abandon it, and it is not too amazing.

Qin Lang said mysteriously to Wu Qingguo: "Of course this is not my research content, this is just some improvement requirements I made casually. The purpose of my visit to the experimental base this time is to optimize and improve the Kunming guinea pig itself. "

"Ah? Kaikun understands."

Wu Qingguo was suddenly shocked by Qin Lang, and even a trace of flame flashed in his eyes, but he didn't regain his senses quickly enough.

Kun understands that the stable inbred line that has been cultivated after many generations of improvement and optimization in the world is a breakthrough where a young man can say a breakthrough.

However, when the words came to his lips, Wu Qingguo directly held back. One was that he didn't want to attack a young man like Qin Lang who still had passion.

After all, this innocent young man full of passion and fantasy is so similar to him back then. Although the result was bitter, there was still some joy in the process.

In addition, he doesn't want to be too busy. Anyway, Mingshi Pharmaceutical Group is not bad for money.

Moreover, this 500-level rat house was originally given to Doctor Qin by Ming Dong casually, and it stopped after playing for half a year and a year.

Wu Qingguo completely took Qin Lang, a subject with a high probability of failure, as a little adjustment and fun in a boring life.

"Doctor Qin, I will report your plan to Dong Ming. Then we will see you next time."

Wu Qingguo and Qin Lang confirmed the next optimization plan. After Qin Lang explained it, he left the mouse house.

Tang Yue had been waiting for him in the car for a long time, and when she saw Qin Lang coming over, she waved:

"Qin Lang, just take a look today, and you can ask Master Wu for more advice later."

Tang Yue looked at Master Wu again, with a playful tone: "Master Wu, you can't hide your secrets!"

Looking at the chairman's daughter, Wu Qingguo was also speechless. It was not certain who was a student and who was a teacher.

"Miss Tang, the words are serious. Physician Qin's accomplishments in raising and cultivating mice are very profound. In some respects, I will also learn from Physician Qin."

Listening to Wu Qingguo's words, Tang Yue was a little stunned. She knew very well that Master Wu was a noble person with a high vision. So she went in to chat and was convinced by Qin Lang's talent?

Tang Yue blinked, this is really Qin Lang's consistent style.

It's just, when will he raise and breed mice again!

Professor Shen even taught this?

When Tang Yue took Qin Lang back to Zijingang No. 1 Hospital, Wu Qingguo also began to arrange the following employees to make a budget according to Qin Lang's previous plan.

Not long after Qin Lang and the others left, Chairman Ming called Wu Qingguo on purpose to ask him what he thought of Qin Lang.

Wu Qingguo reported Qin Lang's ideas and plans in 1510.

After listening to it, Dong Ming was a little surprised. He didn't expect that Doctor Qin was so young and really accomplished in raising and nurturing mice.

As for Qin Lang's ambition to improve and optimize Kunming, Dong Ming was noncommittal, but more or less, he paid more attention to Qin Lang's movements.

"Next, fully cooperate with Dr. Qin to complete his research. Funds and resources are not a problem. The entire research progress can be reported to me at any time."

After giving some orders, Ming Dong hung up the phone. Rather than being interested in this topic, she was more interested in Qin Lang's potential.

After Qin Lang returned to Zijingang First Academy, he went to the desk specially arranged for him by Shenxi, and began to write the paper "Evaluation of Traditional Kunming through Cyclophosphamide (ide, CP) and Colchicine (e, COL. Chromosome aberration experiments in white mice, theoretical research on breeding inbred lines of improved ICR mice.

After the publication of several previous papers, Qin Lang is already a skilled worker. Besides, based on the information of the mice in the drug research and development experiment, Qin Lang wrote a paper of more than 6,000 words very smoothly.

After the paper, Qin Lang theoretically discussed the experimental method of improved mice, created a new system, and focused on the advantages of the new generation of improved ICR mice, which have good motherhood, particularly docile temperament, and robust physique , grow rapidly.

After finishing the paper, Qin Lang directly submitted this theoretical research to "cell" magazine.

"cell" and "Nature" magazine (Nature), "Science" magazine (Sce) and become the world's three most authoritative journals.

These three journals are the journals where most researchers look forward to publishing their work. The two established journals, nature and sce, ~www.novelbuddy.com~ publish articles in a wider range of subjects.

Since "cell" was founded in 1976, it has become one of the most famous journals in the field of natural science research in the world. "cell" mainly publishes important original scientific research reports, and many of the most important journals in the field of life sciences. The findings were published in Cell.

For example, the very famous "artemisinin" in China: the discovery originated from the Chinese herbal medicine garden, this article was published on it, and Tu Ao Ao and her colleagues caused a huge international sensation through this method.

As another example, another very famous article analyzed the association between the population genome and the complex framework of human disease, arguing that the large amount of data obtained by whole-genome sequencing, the 1000 Genomes Project, and targeted genome sequencing revealed rich Rare, individual mutations, which may indicate that recent mutations have a greater impact on disease susceptibility and protection than those occurring in ancient times.

And other important research results, many of the world's big cows have published papers on it.

After Qin Lang submitted the manuscript, he began to design his own topic, and was going to report to Shen Xi first.

ps: Three-in-one chapters, one of which is the previous supplement. Thank you for your support~