MTL - Black Clover: Runaway Asta - Chapter 27

Once all people received Souls and incredible powers. Some were lucky enough to obtain the Soul of an ancient and powerful creature, but fate was not favorable to all.

The world began to change, and creatures evolved. But, it was not the beginning of a new era. It was the end. A couple of months later, a dark mist appeared and destroyed the world. It was a dictate of destiny from which no one could escape.

Wain Norheim was the world's best assassin and the only one who didn't get a soul. However, he was destined to gain the power to confront fate.

Escaping through a portal into another world, he unknowingly began the apocalypse. Even the world failed to expel him.

Beautiful doctor of Chinese medicine, Yu Gangan woke up from a coma one day to a cold, mysterious man. “Excuse me, you are…?”

A pair of profound eyes focused on her and replied, “Fang Zhihan, your husband.”

Did this man take her for a fool? He was obviously a fraud!

A little while down the track, he pulled her into his arms and whispered beside her ear, “Who am I?”

This time, Yu Gangan froze and replied, “Fang Zhihan, my husband.”

If he was a patient, then she was his sweetest medicine…

- Description from Novelupdates

Originally born from a wealthy family, she ends up leading a vagrant life for fifteen years. However, when she is eventually found by her family, she falls into another devious plot and eventually dies tragically.